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TEMPERATURE

Temperature sensorOpen/close loop systemOpen jacket / limpet / dimpled jacket types2 Heat Exchangers – Dedicated PHEX for cooling & PIP for heatingCirculation pump with flow switchHeating & cooling utilities/ in built electrical heater

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PH

pH sensor Acid and alkali dosing bottles Acid & alkali dosing pump, in case of Bioreactor CO2 can be used. All required Valves at appropriate positions. Design for qualification / validation.

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DISSOLVED OXYGEN

Dissolved Oxygen sensor AIR , O2 supply Mass Flow Controller CASCADE mode with selection of aeration, agitation with VFD, O2, B/P. Back Pressure control valve

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NUTRIENT CONENTRATION

Additive lines with aseptic transfer assembly. Respective dosing bottles / integration with NDVs Programmable dosing pumps Sampling valve. PH/DO sensors

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PURITY OF BATCH

Integrity of the system till sterile boundaries. ESIP/FSIP Individual sterilization of addition lines Design with QRM Sterile barrier on exhaust B/P control. CIP

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FOAM

Foam sensor Antifoam dosing bottle Antifoam dosing pump Mechanical Foam Breaker Smart process automation for aeration & agitation.

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